The Grand Palladium Lady Hamilton Resort & Spa is on Jamaica's north coast near the town of Lucea, close to points of interest such as the Rose Hall Great House, Doctor's Cave Beach and the Greenwood Great House. The location makes it a favorite for families and couples.

The Grand Palladium Lady Hamilton Resort & Spa is a blend of contemporary architecture and English colonial influence, with walls in pastel colors enhanced by local artwork and off-white furnishings contrasted with bright cushions. Rooms and one-bedroom suites have furnished terraces with ocean, garden or pool views; some have  outdoor showers.

Together with its sister property, the Grand Palladium Jamaica Resort & Spa, the Grand Palladium Lady Hamilton offers ten restaurant options. There are buffet meals at Mo'Bay, Negril or the Blue Lagoon Restaurant, Indian cuisine at Bhogali, or Asian fusion at Lotus House.  A la carte Pastafarian serves Italian, and El Mariachi offers Mexican cuisine.

Barbecue is on the menu at Bubba's, Creole cuisine at Xamayca, and seafood and local specialties at Poseidon's Sunset Cove.

In addition to water sports offered at the resort or nearby, guests can play tennis, basketball and volleyball. There is also a fitness center and full-service spa.  The Casino Bar has slot machines, and the disco Bobsled is the place for nightlife.